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IONS

Ionis Pharmaceuticals, Inc.

Sector: healthcareBiotechnologyNASDAQMarket Cap: $13.47B

Ionis Pharmaceuticals is a biopharmaceutical company focused on RNA-targeted therapeutics, with its sole political signal being a disclosed dividend-generating stock holding by former President Donald J. Trump.

Govt Dependence
5/100
Regulatory Density
85/100
Lobbying Intensity
0/100
Political Signal
NEUTRAL

BusinessWhat IONS does

Ionis Pharmaceuticals develops and commercializes RNA-targeted therapeutics, primarily for rare diseases. Its revenue is derived from collaborative R&D agreements, royalties, and product sales from partnered and wholly-owned drugs. The company's pipeline is heavily dependent on clinical trial outcomes and regulatory approvals from agencies like the FDA.

12 months past · 3 months futureIONS activity timeline

$89$60$31 JunJulAugSepOctNovDecJan '26FebMarAprMayJunJulAug ↓ PAST — recorded activity ↑ FUTURE — scheduled markups · pending votes TODAY · May 18 $86.50 hi $32.43 lo $75.28 CONGRESS 26 INSIDERS 0 13F FUNDS 30 BILLS 41 Two Sigma Investments · OPENED $210M · 2025-12-31Citadel Advisors · OPENED $165M · 2025-12-31Citadel Advisors · OPENED $157M · 2025-09-30Two Sigma Investments · OPENED $103M · 2025-09-30Two Sigma Investments · OPENED $71M · 2025-06-30Citadel Advisors · OPENED $59M · 2025-06-30Two Sigma Investments · OPENED $48M · 2025-12-31D.E. Shaw & Co. · OPENED $41M · 2025-09-30D.E. Shaw & Co. · OPENED $35M · 2025-12-31Renaissance Technologies · OPENED $32M · 2025-09-30D.E. Shaw & Co. · OPENED $31M · 2025-09-30D.E. Shaw & Co. · OPENED $28M · 2025-06-30Two Sigma Investments · OPENED $27M · 2025-12-31D.E. Shaw & Co. · OPENED $26M · 2025-12-31Renaissance Technologies · OPENED $18M · 2025-12-31Renaissance Technologies · OPENED $11M · 2025-06-30 S.827 · markup · 2025-07-30HR.1860 · committee · 2025-09-16HR.2068 · committee · 2025-06-12 MARKUP · House Appropriations Subcommittee on Department of Homeland · 2026-05-18MARKUP · Senate Appropriations Subcommittee on Commerce, Justice, Sci · 2026-05-19MARKUP · Senate Appropriations Subcommittee on Departments of Labor, · 2026-05-19MARKUP · Senate Appropriations Subcommittee on Department of Defense · 2026-05-19MARKUP · House Appropriations Subcommittee on Commerce, Justice, Scie · 2026-05-19MARKUP · Senate Appropriations Subcommittee on Transportation, Housin · 2026-05-19MARKUP · Senate Budget · 2026-05-20MARKUP · Senate Health, Education, Labor, and Pensions · 2026-05-20MARKUP · House Education and Workforce Subcommittee on Health, Employ · 2026-05-20MARKUP · House Energy and Commerce Subcommittee on Oversight and Inve · 2026-05-20MARKUP · House Energy and Commerce Subcommittee on Health · 2026-05-20MARKUP · Senate Appropriations Subcommittee on Energy and Water Devel · 2026-05-20MARKUP · Senate Veterans' Affairs · 2026-05-20MARKUP · Senate Health, Education, Labor, and Pensions · 2026-05-21MARKUP · Senate Appropriations Subcommittee on Department of Defense · 2026-05-21MARKUP · House Appropriations Subcommittee on Departments of Transpor · 2026-05-21
Congress
buy sell
Insider · Form 4
open-market buy
Hedge fund · 13F
opened + added − trimmed closed holds
Bills
past action (this ticker) upcoming markup (sector) carveout (this ticker)
240 trading days · 0 congressional trades shown · 0 insider buys · 16 13F filings · 3 past bill actions · 16 upcoming markups

Executive Branch ConflictsIONS held by Trump-administration officials

1 cabinet/senior official reported IONS positions in OGE Form 278 disclosures across 1 filings.

Lifetime Government AwardsIONS federal contracts

IONS doesn't hold direct federal contracts.

Verified via USASpending.gov: $0 reported in direct prime-contract awards. Companies in this position typically sell federal services indirectly through prime contractors and integrators (e.g., Lockheed Martin, Booz Allen, Microsoft Azure) or through commercial channels that don't appear in USASpending data.

Smart Money · 13F HoldingsHedge funds holding IONS

$1.67B
Total IONS held by tracked 13F funds
40
Funds with IONS positions
+40
Funds opened this quarter
Two Sigma Investments $210M opened 2025-12-31
Citadel Advisors $165M opened 2025-12-31
Citadel Advisors $157M opened 2025-09-30
Two Sigma Investments $103M opened 2025-09-30
Citadel Advisors $102M opened 2025-03-31
Citadel Advisors $74M opened 2024-12-31
Two Sigma Investments $71M opened 2025-06-30
Citadel Advisors $59M opened 2025-06-30
32 more 13F positions tracked · quarterly delta charts available in member dashboard

Congressional TradesWho in Congress is trading IONS

2023-03-06 Daniel S. Goldman D-New York · house Sale $1,001 - $15,000
2023-03-06 Daniel S. Goldman D-New York · house sale $1,001 - $15,000
2023-03-14 Ro Khanna D-California · house Sale $1,001 - $15,000
2023-03-14 Ro Khanna D-California · house sale $1,001 - $15,000
2023-01-04 Ro Khanna D-California · house Exchange $1,001 - $15,000
2023-01-04 Ro Khanna D-California · house exchange $1,001 - $15,000
2019-05-08 (unknown) purchase $1,001 - $15,000 355d late
2019-06-24 (unknown) sale $1,001 - $15,000 308d late
2019-06-24 (unknown) Sale $1,001 - $15,000 308d late
2019-05-08 (unknown) Purchase $1,001 - $15,000 355d late
2019-04-29 Ro Khanna D-California · house sale $1,001 - $15,000
2019-04-29 Ro Khanna D-California · house Sale $1,001 - $15,000
26+ trades on file · most recent 2023-04-17

Corporate Insiders · Form 4What CEOs, CFOs, and directors are doing with their own stock

No Form 4 activity recorded in the last 180 days.

Bills Affecting IONSLive legislation impacting this stock

Political ProfileWhere IONS sits in Washington

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STRUCTURAL: No lobbying spend (`get_political_influence.lobbying.total_income: 0`), no donations, and no federal contracts (`get_government_precedent.federal_contracts_summary: null`). EVIDENTIARY: One executive branch holding (`get_executive_branch_exposure.by_ticker[0].holdings[0].filer: Donald J. Trump`) with minimal reported value ('None (or less than $1,001)'), zero corporate insider buys in 180 days (`get_corporate_insider_signal.total_buys: 0`), and zero congressional traders. Net: Minimal direct political footprint.

Regulatory ExposureThreats & opportunities

Regulatory threats

  • General legislative pressure on drug pricing and reimbursement
    Congress, HHS
    "Eight recent healthcare bills identified in `Recent bill_impacts` with non-zero impact_ratios."

Regulatory opportunities

  • Potential for favorable orphan drug or accelerated approval pathways
    FDA
    "Inferred from primary industry and sector, but no specific carveouts in `Recent bill_carveouts`."
Member intelligence layer

Live signals + predictions for IONS — for Founders

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Frequently AskedAbout IONS & political exposure

Does Ionis Pharmaceuticals, Inc. (IONS) hold federal contracts?
No direct prime contracts reported in USASpending.gov for Ionis Pharmaceuticals, Inc.. Companies in the semiconductor and AI hardware sectors often sell to the federal government via prime contractors and cloud resellers (Microsoft Azure, AWS, Lockheed Martin systems integration) rather than as direct primes.
Which Trump cabinet officials own IONS stock?
1 Trump cabinet members or senior White House staff have disclosed holdings in IONS on their OGE 278 financial disclosures, including Donald J. Trump. See the Cabinet Conflicts panel for details.
Has Congress traded IONS stock?
26 congressional trades by 5 unique members of Congress, most recently on 2023-03-14. See the Congressional Trading panel for politician-by-politician breakdown.
What is IONS political risk profile?
Government dependence: 5/100. Lobbying intensity: 0/100. Political signal: neutral. Donor party split: R 0% / D 0%.
How does GovGreed track IONS political activity?
GovGreed integrates STOCK Act congressional trade disclosures, FEC contributions, OGE executive-branch disclosures, USASpending federal contracts, Senate LDA lobbying filings, and SEC Form 4 corporate insider trades into a single queryable graph. IONS data is updated daily from these official federal sources.